Description

Follow-up

Within Normal Limits

No abnormal cells detected.

Return for pelvic exam and Pap test in one year.

Atypia

Cells of Uncertain Significance

ASCUS

Some cells show a few changes, or mild atypia. These changes might be due to a type of infection or Human Papilloma Virus (HPV)

There is not one standard management plan for a patient with an
ASCUS Pap smear. The appropriate follow-up and testing will depend on
the patient's personal history. Nevertheless, appropriate evaluation
usually includes a repeat Pap smear and/or colposcopic examination.
Sometimes the inflammation is due to an infection or some other
irritant and resolves with appropriate treatment.

LGSIL

Low Grade Squamous Intraepithelial Lesions

Class III

CIN I (mild dysplasia)

Some normal cells are changed into abnormal cells. These cells could
change into cancer in the future. These changes also are called mild
dysplasia.

Usually, colposcopy is performed after an LGSIL Pap smear. However,
close follow-up only may be warranted depending on the patient's
personal history.

HGSIL

CIN II (moderate dysplasia)

High Grade Squamous Intraepithelial Lesions

Class IV

CIN III (severe dysplasia)

CIS (carcinoma in situ)

This also is called moderate to severe dysplasia.

Colposcopic evaluation is necessary after an HGSIL Pap smear is
discovered. A biopsy may be done to determine the amount of
abnormality. Treatment involves surgical removal of abnormal cells.

Squamous Cancer

Cancer cells are present.

Biopsy to confirm Pap tests and determine treatment. The diagnosis
of cervical cancer must be made by a biopsy. The Pap smear is only a
screening test.